Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13194835 | 0.84 | ALDH1A1 (0.42) | ALDH1A1GRIN2BALOX15POLBSMN1; SMN2 | |
| SCHEMBL15492365 | 0.81 | ALDH1A1 (0.65) | ALDH1A1GRIN2BALOX15POLBLMNA | |
| SCHEMBL14177796 | 0.81 | ALDH1A1 (0.43) | ALDH1A1GRIN2BALOX15POLBSMN1; SMN2 | |
| SCHEMBL16083089 | 0.79 | ALDH1A1 (0.50) | ALDH1A1GRIN2BALOX15POLBSMN1; SMN2 | |
| SCHEMBL22686382 | 0.79 | ALDH1A1 (0.42) | ALDH1A1GRIN2BALOX15POLBSMN1; SMN2 | |
| SCHEMBL25196101 | 0.79 | ALDH1A1 (0.42) | ALDH1A1GRIN2BALOX15POLBSMN1; SMN2 | |
| SCHEMBL15490022 | 0.76 | POLB (0.46) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL22900016 | 0.76 | ALDH1A1 (0.39) | ALDH1A1GRIN2BALOX15POLB | |
| SCHEMBL19265700 | 0.75 | — | — | |
| SCHEMBL14697551 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017147410-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2017-08-31 | — | — | WO | disclosed |