Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 14/20 | 0.53 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.46 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.43 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL190775 | 0.88 | GCK (0.53) | GCKKCNN1KCNN2KCNN3SLC2A1 | |
| SCHEMBL190731 | 0.83 | GCK (0.45) | GCKCACNA2D1CCR4 | |
| SCHEMBL190732 | 0.82 | GCK (0.47) | GCKKCNN1KCNN2KCNN3CCR4 | |
| Hydrochloric Acid SCHEMBL191626 | 0.82 | GCK (0.47) | GCKKCNN1KCNN2KCNN3TGFBR1 | |
| SCHEMBL190972 | 0.82 | GCK (0.47) | GCKKCNN1KCNN2KCNN3TGFBR1 | |
| SCHEMBL190435 | 0.81 | GAA (0.56) | GCKKCNN1KCNN2KCNN3TGFBR1 | |
| SCHEMBL191875 | 0.81 | NPC1 (0.43) | CACNA2D1TGFBR1 | |
| SCHEMBL190467 | 0.81 | GCK (0.54) | GCKKCNN1KCNN2KCNN3SLC2A1 | |
| SCHEMBL191828 | 0.81 | GCK (0.54) | GCKKCNN1KCNN2KCNN3SLC2A1 | |
| SCHEMBL12305690 | 0.80 | GCK (0.47) | GCKKCNN1KCNN2KCNN3GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986645-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2012-01-04 | — | — | EP | disclosed |