Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 11/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.46 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.46 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL191626 | 0.91 | GCK (0.47) | GCKGRM5KCNN1KCNN2KCNN3 | |
| SCHEMBL190659 | 0.83 | GCK (0.59) | GCKGRM5KCNN1KCNN2KCNN3 | |
| SCHEMBL191056 | 0.82 | TRPV4 (0.56) | GCKGRM5KCNN1KCNN2KCNN3 | |
| SCHEMBL190754 | 0.82 | GRM5 (0.67) | GCKGRM5TRPV4TGFBR1 | |
| SCHEMBL192859 | 0.82 | GCK (0.53) | GCKGRM5KCNN1KCNN2KCNN3 | |
| SCHEMBL190670 | 0.81 | MEN1 (0.54) | GCKGRM5KCNN1KCNN2KCNN3 | |
| SCHEMBL191592 | 0.81 | TRPV4 (0.56) | GCKGRM5KCNN1KCNN2KCNN3 | |
| SCHEMBL191359 | 0.80 | GRM5 (0.48) | GCKGRM5KCNN1KCNN2KCNN3 | |
| SCHEMBL191025 | 0.80 | GCK (0.51) | GCKGRM5KCNN1KCNN2KCNN3 | |
| SCHEMBL190744 | 0.79 | TRPV4 (0.47) | GCKGRM5KCNN1KCNN2KCNN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986645-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2012-01-04 | — | — | EP | disclosed |