Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947259 | 0.87 | NR1H4 (0.80) | NR1H4KMT2ANPC1ALDH1A1RAB9A | |
| SCHEMBL13932522 | 0.86 | ALDH1A1 (0.78) | NR1H4KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL23894774 | 0.85 | NR1H4 (0.72) | NR1H4KMT2ANPC1ALDH1A1RAB9A | |
| SCHEMBL13947076 | 0.84 | NR1H4 (0.71) | NR1H4KMT2ANPC1ALDH1A1KDM4E | |
| SCHEMBL19490332 | 0.84 | NR1H4 (0.70) | NR1H4KMT2ANPC1ALDH1A1RAB9A | |
| SCHEMBL17231376 | 0.83 | ALDH1A1 (0.60) | NR1H4KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL23095209 | 0.82 | NR1H4 (0.67) | NR1H4KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL23894773 | 0.82 | NR1H4 (0.67) | NR1H4KMT2ANPC1ALDH1A1RAB9A | |
| SCHEMBL22580650 | 0.81 | NR1H4 (0.67) | NR1H4KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL22580579 | 0.80 | NR1H4 (0.65) | NR1H4KMT2ANPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9744171-B2 | Positive allosteric modulators for melanocortin receptors | VANDERBILT UNIVERSITY (US) | 2017-08-29 | — | — | US | disclosed |