Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PREP | P48147 | 1/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.46 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011990 | 0.88 | HTR2C (0.53) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL15765907 | 0.85 | HTR2C (0.48) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL10053573 | 0.85 | HTR2C (0.64) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL5517077 | 0.85 | HTR2C (0.64) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL5517082 | 0.85 | HTR2C (0.64) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL14883057 | 0.84 | HTR2C (0.54) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL16770908 | 0.84 | HTR2C (0.54) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL14876889 | 0.84 | HTR2C (0.54) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL15825289 | 0.84 | HTR2C (0.54) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL14883060 | 0.84 | HTR2C (0.54) | HTR2CPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745284-B2 | 2-pyridyloxy-4-ether orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-08-29 | — | — | US | disclosed |