Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.32 |
| ▸ | IGF1R | P08069 | 2/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | TTK | P33981 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11900968 | 0.82 | ALK (0.51) | ALKIGF1RINSRZAP70EGFR | |
| SCHEMBL11900973 | 0.76 | ALK (0.51) | ALKIGF1RINSRZAP70EGFR | |
| SCHEMBL19288667 | 0.71 | ALK (0.37) | ALKIGF1RINSRZAP70JAK2 | |
| SCHEMBL11900970 | 0.70 | ALK (0.51) | ALKIGF1RINSRZAP70EGFR | |
| SCHEMBL11901068 | 0.61 | ALK (0.57) | ALKIGF1RINSRZAP70EGFR | |
| SCHEMBL13395666 | 0.60 | ALK (0.60) | ALKIGF1RINSRZAP70PTK2 | |
| SCHEMBL1493535 | 0.60 | ALK (0.60) | ALKINSR | |
| SCHEMBL13395669 | 0.59 | ALK (0.77) | ALKIGF1RINSRZAP70JAK2 | |
| SCHEMBL13395660 | 0.58 | ALK (0.56) | ALKIGF1RINSRZAP70PTK2 | |
| SCHEMBL11916458 | 0.56 | ALK (0.80) | ALKIGF1RINSRZAP70JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3210609-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2017-08-30 | — | — | EP | disclosed |