Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.37 |
| ▸ | INSR | P06213 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11916333 | 0.79 | ALK (0.60) | ALKINSRLRRK2ZAP70EGFR | |
| SCHEMBL17527282 | 0.71 | ALK (0.60) | ALKINSRLRRK2IGF1R | |
| SCHEMBL19288509 | 0.71 | ALK (0.32) | ALKINSRZAP70JAK2EGFR | |
| SCHEMBL1493535 | 0.67 | ALK (0.60) | ALKINSRLRRK2 | |
| SCHEMBL15206515 | 0.65 | ALK (0.63) | ALKINSRLRRK2MAPK9MAPK10 | |
| SCHEMBL11900623 | 0.64 | ALK (0.34) | ALKINSRLRRK2 | |
| SCHEMBL11901894 | 0.63 | ALK (0.59) | ALKINSRLRRK2CHEK1AURKA | |
| SCHEMBL11916458 | 0.61 | ALK (0.80) | ALKINSRLRRK2MAPK9MAPK10 | |
| SCHEMBL19288535 | 0.61 | ALK (0.56) | ALKINSRLRRK2ZAP70EGFR | |
| SCHEMBL1493647 | 0.61 | ALK (0.61) | ALKINSRLRRK2CHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3210609-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2017-08-30 | — | — | EP | disclosed |