Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 15/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.80 |
| ▸ | EGFR | P00533 | 2/20 | 0.63 |
| ▸ | INSR | P06213 | 2/20 | 0.63 |
| ▸ | LCK | P06239 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.63 |
| ▸ | MET | P08581 | 1/20 | 0.63 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.63 |
| ▸ | PLK4 | O00444 | 1/20 | 0.63 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.63 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.63 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1928863 | 1.00 | IGF1R (0.80) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL1928874 | 1.00 | IGF1R (0.80) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL1926362 | 0.90 | IGF1R (0.73) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL1926365 | 0.90 | IGF1R (0.73) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL1926366 | 0.90 | IGF1R (0.73) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL5147090 | 0.89 | IGF1R (1.00) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL5072442 | 0.85 | IGF1R (0.87) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL5988484 | 0.84 | IGF1R (0.74) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL6093942 | 0.83 | IGF1R (0.77) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL5140708 | 0.83 | IGF1R (0.79) | IGF1RCYP3A4CYP2C19CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956190-B2 | Benzimidazole amido derivatives as kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2011-06-07 | — | — | US | claimed |
| US-20100168181-A1 | BENZIMIDAZOLE AMIDO DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2010-07-01 | — | — | US | claimed |
| EP-2170859-A1 | BENZIMIDAZOLE AMIDO DERIVATIVES AS KINASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2010-04-07 | — | — | EP | claimed |
| WO-2009000489-A1 | BENZIMIDAZOLE AMIDO DERIVATIVES AS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-31 | — | — | WO | claimed |
| US-7956190-B2 | Benzimidazole amido derivatives as kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2011-06-07 | — | — | US | disclosed |
| US-20100168181-A1 | BENZIMIDAZOLE AMIDO DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2010-07-01 | — | — | US | disclosed |
| EP-2170859-A1 | BENZIMIDAZOLE AMIDO DERIVATIVES AS KINASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009000489-A1 | BENZIMIDAZOLE AMIDO DERIVATIVES AS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168181-A1 | BENZIMIDAZOLE AMIDO DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | CYP3A5, TMBIM6, FANCI | IGF1R 1443/4885CYP3A4 13/4885CYP2C19 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.