Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.48 |
| ▸ | MME | P08473 | 5/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653074 | 1.00 | PPARG (0.49) | PPARGAGTR1MMEAGTR2 | |
| SCHEMBL651920 | 0.89 | MME (0.48) | PPARGAGTR1MMEAGTR2 | |
| SCHEMBL651961 | 0.86 | AGTR2 (0.42) | AGTR1MMEAGTR2 | |
| SCHEMBL652532 | 0.86 | MME (0.40) | AGTR1MME | |
| SCHEMBL654691 | 0.86 | PPARG (0.48) | PPARGAGTR1MMEAGTR2 | |
| SCHEMBL654692 | 0.86 | PPARG (0.48) | PPARGAGTR1MMEAGTR2 | |
| SCHEMBL15253877 | 0.85 | MME (0.49) | MME | |
| SCHEMBL653868 | 0.85 | MME (0.40) | PPARGAGTR1MME | |
| SCHEMBL655018 | 0.84 | MME (0.47) | AGTR1MMEAGTR2 | |
| SCHEMBL9427910 | 0.82 | PPARG (0.62) | PPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956054-B2 | Dual-acting pyrazole antihypertensive agents | THERAVANCE, INC. (US) | 2011-06-07 | — | — | US | disclosed |