Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 6/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13881847 | 0.88 | BCHE (0.40) | CYP2D6BCHEACHENOS1NOS2 | |
| SCHEMBL13881720 | 0.87 | CHRM2 (0.48) | CYP2D6BCHEACHECHRM2CHRM1 | |
| SCHEMBL13881804 | 0.85 | CHRM2 (0.50) | CYP2D6BCHEACHECHRM2CHRM1 | |
| SCHEMBL13881944 | 0.78 | BCHE (0.37) | CYP2D6BCHECHRM2CHRM1CHRM3 | |
| SCHEMBL25818121 | 0.77 | BCHE (0.43) | CYP2D6BCHEKCNH2PPARGPPARA | |
| SCHEMBL20318730 | 0.77 | PPARA (0.49) | CYP2D6BCHEKCNH2PPARGPPARA | |
| SCHEMBL13881576 | 0.76 | BCHE (0.42) | CYP2D6BCHEKCNH2PPARGPPARA | |
| SCHEMBL4568761 | 0.76 | PPARA (0.51) | CYP2D6BCHEKCNH2PPARGPPARA | |
| SCHEMBL13881782 | 0.76 | PRMT5 (0.38) | CYP2D6ACHEPPARGPPARA | |
| SCHEMBL4568762 | 0.75 | PPARA (0.52) | CYP2D6BCHEKCNH2PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3210966-A1 | ALKOXYPHENYLPROPYLAMINES FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION | Acucela, Inc. (US) | 2017-08-30 | — | — | EP | disclosed |