Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2F2 | P24468 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1930614 | 1.00 | NR2F2 (0.60) | NR2F2RAB9AALDH1A1SIGMAR1TDP1 | |
| SCHEMBL828909 | 0.91 | SIGMAR1 (0.64) | NR2F2RAB9AALDH1A1SIGMAR1TDP1 | |
| SCHEMBL13799649 | 0.89 | SIGMAR1 (0.65) | NR2F2RAB9AALDH1A1SIGMAR1TDP1 | |
| SCHEMBL17742668 | 0.88 | SIGMAR1 (0.58) | NR2F2RAB9AALDH1A1SIGMAR1TDP1 | |
| SCHEMBL4422293 | 0.87 | SIGMAR1 (0.55) | NR2F2RAB9AALDH1A1SIGMAR1TDP1 | |
| SCHEMBL14542604 | 0.85 | TDP1 (0.52) | NR2F2RAB9AALDH1A1SIGMAR1TDP1 | |
| SCHEMBL25148116 | 0.85 | SIGMAR1 (0.53) | NR2F2RAB9AALDH1A1SIGMAR1TDP1 | |
| SCHEMBL9547316 | 0.84 | NR2F2 (0.47) | NR2F2RAB9AALDH1A1SIGMAR1MEN1 | |
| SCHEMBL11992513 | 0.84 | SIGMAR1 (0.53) | NR2F2RAB9AALDH1A1SIGMAR1TDP1 | |
| SCHEMBL9358258 | 0.84 | GLA (0.54) | NR2F2RAB9AALDH1A1SIGMAR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956059-B2 | Aliphatic amide and ester pyrazinoylguanidine sodium channel blockers | PARION SCIENCES, INC. (US) | 2011-06-07 | — | — | US | disclosed |
| US-20090227594-A1 | ALIPHATIC AMIDE & ESTER PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227594-A1 | ALIPHATIC AMIDE & ESTER PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | KCNH2, CACNA1B, SCNN1G | NR2F2 4237/4885RAB9A 1264/4885ALDH1A1 1322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.