Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19294659 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2CA1CA2KMT2APOLB | |
| SCHEMBL7643619 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2CA1CA2KMT2APOLB | |
| SCHEMBL3799883 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2CA1CA2KMT2APOLB | |
| SCHEMBL16368818 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2CA1CA2KMT2APOLB | |
| SCHEMBL8223673 | 0.72 | CA1 (0.43) | SMN1; SMN2CA1CA2POLBNOS3 | |
| SCHEMBL15041053 | 0.72 | CA1 (0.43) | SMN1; SMN2CA1CA2POLBNOS3 | |
| SCHEMBL16486923 | 0.72 | SMN1; SMN2 (0.50) | SMN1; SMN2CA1CA2POLBNOS3 | |
| SCHEMBL12890253 | 0.72 | CA1 (0.43) | SMN1; SMN2CA1CA2POLBNOS3 | |
| SCHEMBL15041052 | 0.72 | CA1 (0.43) | SMN1; SMN2CA1CA2POLBNOS3 | |
| SCHEMBL11041537 | 0.72 | CA1 (0.43) | SMN1; SMN2CA1CA2POLBNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170247338-A1 | PROCESS FOR PREPARING (CYCLOPENTYL[d]PYRIMIDIN-4-YL)PIPERAZINE COMPOUNDS | F. HOFFMAN-LA ROCHE AG (CH) | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247338-A1 | PROCESS FOR PREPARING (CYCLOPENTYL[d]PYRIMIDIN-4-YL)PIPERAZINE COMPOUNDS | PAK5, CDK5, PPIP5K2 | SMN1; SMN2 2538/4885CA1 3628/4885CA2 3564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.