Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.62 |
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27631763 | 1.00 | SYK (0.62) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL19297747 | 0.87 | AURKA (0.52) | SYKAURKA | |
| SCHEMBL19297743 | 0.84 | SYK (0.63) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL19297744 | 0.84 | SYK (0.47) | SYKAURKA | |
| SCHEMBL19297721 | 0.84 | SYK (0.55) | SYKAURKA | |
| SCHEMBL12389631 | 0.83 | SYK (0.57) | SYKAURKA | |
| SCHEMBL12440229 | 0.83 | SYK (0.55) | SYK | |
| SCHEMBL19297717 | 0.83 | SYK (0.69) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL19297758 | 0.82 | SYK (0.60) | SYKAURKAMAPK8AURKBCDK19 | |
| SCHEMBL19297727 | 0.82 | SYK (0.54) | SYKAURKAMAPK8AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751893-B2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | claimed |