Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 7/20 | 0.47 |
| ▸ | ITK | Q08881 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | BCL6 | P41182 | 6/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19297727 | 0.91 | SYK (0.54) | SYKAURKAEGFRITKPTK2 | |
| SCHEMBL19297721 | 0.89 | SYK (0.55) | SYKAURKAEGFR | |
| SCHEMBL19297747 | 0.87 | AURKA (0.52) | SYKAURKAEGFR | |
| SCHEMBL19297718 | 0.84 | SYK (0.48) | SYKAURKAEGFRITKPTK2 | |
| SCHEMBL19297726 | 0.84 | EGFR (0.48) | SYKAURKAEGFRITKPTK2 | |
| SCHEMBL27631763 | 0.84 | SYK (0.62) | SYKAURKA | |
| SCHEMBL19297729 | 0.84 | SYK (0.62) | SYKAURKA | |
| SCHEMBL12389631 | 0.83 | SYK (0.57) | SYKAURKAEGFR | |
| SCHEMBL12440229 | 0.83 | SYK (0.55) | SYK | |
| SCHEMBL19297760 | 0.82 | EGFR (0.45) | SYKAURKAEGFRITKPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751893-B2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | claimed |