Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.55 |
| ▸ | AURKA | O14965 | 7/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | STK25 | O00506 | 1/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14837242 | 0.89 | SYK (0.56) | SYKAURKAJAK2EGFRLCK | |
| SCHEMBL19297726 | 0.89 | EGFR (0.48) | SYKAURKAJAK2EGFRLCK | |
| SCHEMBL19297752 | 0.89 | AURKA (0.53) | SYKAURKAJAK2EGFRLCK | |
| SCHEMBL19297748 | 0.86 | BCL6 (0.58) | SYKAURKAEGFRSTK17BPTK2 | |
| SCHEMBL1381667 | 0.85 | SYK (0.51) | SYKAURKAJAK2EGFRLCK | |
| SCHEMBL19297721 | 0.84 | SYK (0.55) | SYKAURKAJAK2EGFRLCK | |
| SCHEMBL19297722 | 0.84 | SYK (0.57) | SYKAURKAJAK2EGFRJAK1 | |
| SCHEMBL19297743 | 0.83 | SYK (0.63) | SYKAURKAMAPK8AURKB | |
| SCHEMBL2103278 | 0.83 | SYK (0.69) | SYKAURKAJAK2EGFRLCK | |
| SCHEMBL12389639 | 0.83 | SYK (0.58) | SYKEGFRCDK1CDC7PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751893-B2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | claimed |