Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.53 |
| ▸ | SYK | P43405 | 13/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19297732 | 0.89 | SYK (0.55) | AURKASYKCDK1EGFRJAK2 | |
| SCHEMBL14837242 | 0.87 | SYK (0.56) | AURKASYKCDK1EGFRJAK2 | |
| SCHEMBL19297726 | 0.87 | EGFR (0.48) | AURKASYKCDK1EGFRJAK2 | |
| SCHEMBL19297743 | 0.87 | SYK (0.63) | AURKASYK | |
| SCHEMBL1135756 | 0.86 | CDK1 (0.51) | AURKASYKCDK1EGFRJAK2 | |
| SCHEMBL12389639 | 0.86 | SYK (0.58) | SYKCDK1EGFR | |
| SCHEMBL12389645 | 0.84 | SYK (0.62) | AURKASYKCDK1EGFRJAK2 | |
| SCHEMBL19297748 | 0.84 | BCL6 (0.58) | AURKASYKEGFR | |
| SCHEMBL1381667 | 0.83 | SYK (0.51) | AURKASYKCDK1EGFRJAK2 | |
| SCHEMBL19297747 | 0.83 | AURKA (0.52) | AURKASYKCDK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751893-B2 | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | claimed |