Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.38 |
| ▸ | JAK1 | P23458 | 14/20 | 0.38 |
| ▸ | TYK2 | P29597 | 14/20 | 0.38 |
| ▸ | JAK3 | P52333 | 10/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19300020 | 0.85 | JAK2 (0.37) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL19300145 | 0.78 | JAK2 (0.35) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL19299971 | 0.77 | JAK2 (0.50) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL21033570 | 0.73 | FYN (0.42) | MAPT | |
| SCHEMBL17801193 | 0.70 | JAK2 (0.41) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL24438250 | 0.70 | JAK2 (0.43) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL17801236 | 0.68 | CHEK1 (0.47) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL19299855 | 0.68 | JAK2 (0.56) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL19253504 | 0.67 | JAK2 (0.48) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL30038166 | 0.67 | JAK2 (0.41) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144995-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | PFIZER INC. (US) | 2017-08-31 | — | — | WO | disclosed |