Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 6/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.37 |
| ▸ | MET | P08581 | 5/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.36 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033576 | 0.81 | KDM4E (0.60) | FYNPIK3CGNPC1RAB9AKDM4E | |
| SCHEMBL21033596 | 0.80 | PIK3CG (0.51) | FYNPIK3CGGRK5CHEK1RIPK1 | |
| SCHEMBL30845796 | 0.78 | GRM2 (0.49) | FYNPIK3CGGRK5CHEK1RIPK1 | |
| SCHEMBL19300033 | 0.73 | JAK2 (0.38) | MAPT | |
| SCHEMBL19300145 | 0.68 | JAK2 (0.35) | CHEK1MAPT | |
| SCHEMBL19338499 | 0.66 | FYN (0.48) | FYNGRK5KDM4ECHEK1MET | |
| SCHEMBL3409540 | 0.66 | DYRK1A (0.58) | FYNGRK5CHEK1METDYRK1A | |
| SCHEMBL21033944 | 0.65 | KDM4E (0.31) | NPC1RAB9AKDM4ERXFP1KMT2A | |
| SCHEMBL16136540 | 0.64 | FYN (0.61) | FYNGRK5CHEK1METDYRK1A | |
| SCHEMBL3487219 | 0.63 | CSNK1D (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019102494-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | JUBILANT BIOSYS LIMITED (IN) | 2019-05-31 | — | — | WO | disclosed |