Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.64 |
| ▸ | JAK1 | P23458 | 8/20 | 0.64 |
| ▸ | TYK2 | P29597 | 8/20 | 0.64 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | RET | P07949 | 12/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21872437 | 0.84 | JAK1 (0.62) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL19299892 | 0.82 | JAK1 (0.65) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22449691 | 0.82 | JAK2 (0.71) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL20793958 | 0.80 | JAK2 (0.78) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL19253407 | 0.78 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL19253409 | 0.78 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL19276457 | 0.76 | JAK2 (0.64) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL20793959 | 0.73 | JAK2 (0.84) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL21872233 | 0.71 | TYK2 (0.55) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL19253538 | 0.71 | JAK2 (0.47) | JAK2JAK1TYK2JAK3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144995-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | PFIZER INC. (US) | 2017-08-31 | — | — | WO | disclosed |