Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 12/20 | 0.62 |
| ▸ | JAK2 | O60674 | 11/20 | 0.62 |
| ▸ | TYK2 | P29597 | 11/20 | 0.62 |
| ▸ | JAK3 | P52333 | 11/20 | 0.62 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 6/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19300034 | 0.84 | JAK2 (0.64) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL22449704 | 0.80 | JAK1 (0.66) | JAK1JAK2TYK2JAK3CLK2 | |
| SCHEMBL19299994 | 0.80 | JAK1 (0.94) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL17801247 | 0.76 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL19300148 | 0.75 | JAK2 (0.48) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL19276457 | 0.73 | JAK2 (0.64) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL24248136 | 0.72 | JAK2 (0.46) | JAK1JAK2TYK2JAK3CLK2 | |
| SCHEMBL19253460 | 0.72 | JAK2 (0.47) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL19253538 | 0.72 | JAK2 (0.47) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL20793958 | 0.72 | JAK2 (0.78) | JAK1JAK2TYK2JAK3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3712153-B1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | PFIZER (US) | 2021-12-01 | — | — | EP | disclosed |
| EP-3712153-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | Pfizer Inc (US) | 2020-09-23 | — | — | EP | disclosed |
| EP-3419978-B1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | PFIZER (US) | 2020-04-15 | — | — | EP | disclosed |