Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801168 | 0.78 | MAPT (0.42) | KDM4ERXFP1 | |
| SCHEMBL17801193 | 0.77 | JAK2 (0.41) | NPC1RAB9AKDM4ERXFP1KMT2A | |
| SCHEMBL29571231 | 0.69 | MAPT (0.43) | NPC1RAB9AKDM4ERXFP1 | |
| SCHEMBL25236672 | 0.69 | CHEK1 (0.39) | KDM4E | |
| SCHEMBL24438250 | 0.68 | JAK2 (0.43) | NPC1RAB9AKDM4ERXFP1KMT2A | |
| SCHEMBL17801359 | 0.67 | ERCC5 (0.42) | NPC1RAB9AKDM4EKMT2A | |
| SCHEMBL15175885 | 0.67 | CYP1A2 (0.43) | NPC1RAB9AKDM4ERXFP1KMT2A | |
| SCHEMBL17801236 | 0.63 | CHEK1 (0.47) | — | |
| SCHEMBL21872222 | 0.61 | CHEK1 (0.39) | — | |
| SCHEMBL12020383 | 0.60 | FAAH (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144995-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | PFIZER INC. (US) | 2017-08-31 | — | — | WO | disclosed |