Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA5 | P08648 | 1/20 | 0.47 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.47 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19300932 | 0.94 | SMN1; SMN2 (0.44) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283608 | 0.91 | ITGA5 (0.45) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283561 | 0.90 | ITGA5 (0.45) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283620 | 0.90 | ITGA5 (0.45) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283850 | 0.90 | ITGA5 (0.48) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283463 | 0.90 | LMNA (0.48) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283808 | 0.89 | ITGA5 (0.47) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19301304 | 0.89 | ITGA5 (0.44) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL30645019 | 0.89 | NPC1 (0.47) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL20743761 | 0.89 | NPC1 (0.47) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144183-A1 | NOVEL POTASSIUM CHANNEL INHIBITORS | ACESION PHARMA APS (DK) | 2017-08-31 | — | — | WO | disclosed |