Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10821124 | 0.89 | MC4R (0.45) | MC4RMAPTKDM4EKMT2AMEN1 | |
| SCHEMBL10820829 | 0.84 | MC4R (0.46) | MC4RMAPTKDM4EKMT2AMEN1 | |
| SCHEMBL5991400 | 0.84 | MC4R (0.41) | MC4RMAPTKDM4EKMT2AMEN1 | |
| SCHEMBL3736618 | 0.78 | MC4R (0.67) | MC4RMAPTKDM4EKMT2AMEN1 | |
| SCHEMBL11811558 | 0.77 | MC4R (0.51) | MC4RMAPTKDM4EKMT2AMEN1 | |
| SCHEMBL10943737 | 0.73 | HPGD (0.49) | MAPTKDM4EKMT2AGAAHSD17B10 | |
| SCHEMBL11276936 | 0.72 | MAPT (0.60) | MAPTKDM4EKMT2AMEN1HSP90AA1 | |
| SCHEMBL11801791 | 0.70 | KDM4E (0.54) | MAPTKDM4EKMT2AMEN1NPC1 | |
| SCHEMBL1930724 | 0.69 | HDAC4 (0.41) | MAPTKDM4EKMT2AMEN1HDAC4 | |
| SCHEMBL11282298 | 0.69 | ALDH1A1 (0.52) | MAPTKDM4EKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956070-B2 | Piperidines as chemokine modulators (CCR) | ASTRAZENECA AB (SE) | 2011-06-07 | — | — | US | disclosed |
| CN-101466378-A | Piperidine derivatives for the treatment of osteoarthritis and osteoarthrosis | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | disclosed |
| EP-2010175-A1 | PIPERIDINE DERIVATIVES USEFUL FOR TREATING OSTEOARTHRITIS AND OSTEOARTROSIS | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| US-20080108661-A1 | Medicaments | ASTRAZENECA AB | 2008-05-08 | — | — | US | disclosed |
| WO-2007114770-A1 | PIPERIDINE DERIVATIVES USEFUL FOR TREATING OSTEOARTHRITIS AND OSTEOARTROSIS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |
| CN-1938274-A | Novel piperidines as chemokine modulators (CCR) | ASTRAZENECA AB (SE) | 2007-03-28 | — | — | CN | disclosed |
| US-20070054924-A1 | Novel piperidines as chemokine modulators (ccr) | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | US | disclosed |
| EP-1713772-A1 | NOVEL PIPERIDINES AS CHEMOKINE MODULATORS (CCR) | AstraZeneca AB (SE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005073192-A1 | NOVEL PIPERIDINES AS CHEMOKINE MODULATORS (CCR) | ASTRAZENECA AB (SE) | 2005-08-11 | — | — | WO | disclosed |
| US-5008281-A | Insecticides, miticides, nematocides | ROUSSEL UCLAF (FR) | 1991-04-16 | — | — | US | disclosed |
| US-4925862-A | PESTICIDES | ROUSSEL UCLAF (FR) | 1990-05-15 | — | — | US | disclosed |
| US-4602937-A | PLANT SAFENING AGENTS, ACETAMIDE HERBICIDE | MONSANTO COMPANY (US) | 1986-07-29 | — | — | US | disclosed |
| US-4602454-A | PLANT SAFENING AGENTS, SEEDS CHLOROACETAMIDE HERBICIDES | MONSANTO COMPANY (US) | 1986-07-29 | — | — | US | disclosed |
| US-4586948-A | 2,4-disubstituted-5-thiazole-carboxylic acids and derivatives | MONSANTO COMPANY (US) | 1986-05-06 | — | — | US | disclosed |
| US-4437876-A | PLANT SAFENING AGENTS FOR ACETAMIDE HERBICIDES | MONSANTO COMPANY (US) | 1984-03-20 | — | — | US | disclosed |
| US-4437875-A | PLANT SAFENING AGENT FOR ACETAMIDE HERBICIDE | MONSANTO COMPANY (US) | 1984-03-20 | — | — | US | disclosed |
| US-4251261-A | PLANT GROWTH REGULATORS; USE WITH HERBICIDAL 2-CHLORO-N-(2-METHOXY-1-METHYLETHYL)-6'-ETHYL-O-ACETOTOLUIDIDE | MONSANTO COMPANY (US) | 1981-02-17 | — | — | US | disclosed |
| US-4199506-A | REDUCES HERBICIDAL INJURY TO PLATNS DUE TO ACETAMIDE HERBICIDES | MONSANTO COMPANY (US) | 1980-04-22 | — | — | US | disclosed |
| US-3932436-A | 2-Thiazolone-5-carboxylic acid ester fungicidal agents | BAYER AKTIENGESELLSCHAFT (DT) | 1976-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054924-A1 | Novel piperidines as chemokine modulators (ccr) | CCR3, CCR1, CCR4 | MC4R 702/4885MAPT 4473/4885KDM4E 3873/4885 |
| US-20080108661-A1 | Medicaments | CCR3, CCR1, CCR6 | MC4R 371/4885MAPT 4678/4885KDM4E 4574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.