Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA5 | P08648 | 1/20 | 0.51 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.51 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.51 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19283598 | 0.92 | ITGA5 (0.48) | ITGA5ITGB6ITGB8CACNA2D1CACNA1B | |
| SCHEMBL19301231 | 0.92 | ITGA5 (0.46) | ITGA5ITGB6ITGB8CACNA2D1CACNA1B | |
| SCHEMBL19283587 | 0.91 | ITGA5 (0.46) | ITGA5ITGB6ITGB8CACNA2D1CACNA1B | |
| SCHEMBL19283529 | 0.90 | ITGA5 (0.48) | ITGA5ITGB6ITGB8CACNA2D1CACNA1B | |
| SCHEMBL19283550 | 0.89 | ITGA5 (0.47) | ITGA5ITGB6ITGB8CACNA2D1CACNA1B | |
| SCHEMBL19283527 | 0.89 | ITGA5 (0.47) | ITGA5ITGB6ITGB8CACNA2D1CACNA1B | |
| SCHEMBL19283577 | 0.87 | ITGA5 (0.51) | ITGA5ITGB6ITGB8CACNA2D1CACNA1B | |
| SCHEMBL19283613 | 0.86 | ITGB6 (0.55) | ITGA5ITGB6ITGB8NPC1RAB9A | |
| SCHEMBL20743761 | 0.84 | NPC1 (0.47) | ITGA5ITGB6ITGB8NPC1RAB9A | |
| SCHEMBL19283637 | 0.84 | ITGA5 (0.47) | ITGA5ITGB6ITGB8NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144183-A1 | NOVEL POTASSIUM CHANNEL INHIBITORS | ACESION PHARMA APS (DK) | 2017-08-31 | — | — | WO | disclosed |