Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA5 | P08648 | 1/20 | 0.46 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.46 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19301133 | 0.92 | ITGA5 (0.51) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283598 | 0.84 | ITGA5 (0.48) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283587 | 0.83 | ITGA5 (0.46) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19301135 | 0.83 | NPC1 (0.45) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283529 | 0.82 | ITGA5 (0.48) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283577 | 0.82 | ITGA5 (0.51) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19300932 | 0.81 | SMN1; SMN2 (0.44) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283550 | 0.81 | ITGA5 (0.47) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283527 | 0.81 | ITGA5 (0.47) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19301053 | 0.81 | SMN1; SMN2 (0.43) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144183-A1 | NOVEL POTASSIUM CHANNEL INHIBITORS | ACESION PHARMA APS (DK) | 2017-08-31 | — | — | WO | disclosed |