Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 7/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | TEK | Q02763 | 6/20 | 0.47 |
| ▸ | SRC | P12931 | 5/20 | 0.47 |
| ▸ | ADK | P55263 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 8/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18496750 | 0.81 | ADK (0.46) | LCKKDRTEKSRCADK | |
| SCHEMBL29589509 | 0.81 | ADK (0.46) | LCKKDRTEKSRCADK | |
| SCHEMBL25612067 | 0.81 | ADK (0.46) | LCKKDRTEKSRCADK | |
| SCHEMBL6935719 | 0.80 | ADK (0.48) | LCKKDRTEKSRCADK | |
| SCHEMBL19304156 | 0.79 | SRC (0.62) | LCKKDRTEKSRCADK | |
| SCHEMBL21178837 | 0.78 | LCK (0.43) | LCKKDRTEKSRCRET | |
| SCHEMBL31639574 | 0.78 | LCK (0.43) | LCKKDRTEKSRCRET | |
| SCHEMBL14725430 | 0.77 | SRC (0.43) | LCKKDRTEKSRCRET | |
| SCHEMBL17705872 | 0.75 | ADK (0.47) | SRCADKEGFRMEN1NR2F2 | |
| SCHEMBL31639615 | 0.74 | LCK (0.40) | LCKKDRTEKSRCADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3641776-B1 | ATROPISOMERISM FOR ENHANCED KINASE INHIBITOR SELECTIVITY | SAN DIEGO STATE UNIV RESEARCH FOUNDATION (US) | 2023-10-18 | — | — | EP | disclosed |
| EP-3269370-A1 | NOVEL CONDENSED PYRIMIDINE COMPOUND OR SALT THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2018-01-17 | — | — | EP | disclosed |
| WO-2017146116-A1 | NOVEL CONDENSED PYRIMIDINE COMPOUND OR SALT THEREOF | 大鵬薬品工業株式会社 | 2017-08-31 | — | — | WO | disclosed |