Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.41 |
| ▸ | GABRE | P78334 | 2/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL27851898 | 1.00 | TDP1 (0.43) | TDP1GABRPGABRDGABRA1GABRB1 | |
| Propylene Glycol SCHEMBL7907781 | 0.91 | TDP1 (0.53) | TDP1GABRPGABRDGABRA1GABRB1 | |
| Propylene Glycol SCHEMBL1930685 | 0.91 | TDP1 (0.53) | TDP1GABRPGABRDGABRA1GABRB1 | |
| Maleic Acid SCHEMBL29843257 | 0.89 | TDP1 (0.56) | TDP1GABRPGABRDGABRA1GABRB1 | |
| Fumaric Acid SCHEMBL27471991 | 0.89 | TDP1 (0.56) | TDP1GABRPGABRDGABRA1GABRB1 | |
| Fumaric Acid SCHEMBL1043268 | 0.89 | TDP1 (0.56) | TDP1GABRPGABRDGABRA1GABRB1 | |
| Maleic Acid SCHEMBL9362830 | 0.89 | TDP1 (0.56) | TDP1GABRPGABRDGABRA1GABRB1 | |
| Fumaric Acid SCHEMBL9856664 | 0.89 | TDP1 (0.56) | TDP1GABRPGABRDGABRA1GABRB1 | |
| Maleic Acid SCHEMBL28454524 | 0.84 | TDP1 (0.50) | TDP1GABRPGABRDGABRA1GABRB1 | |
| Ethylene Glycol SCHEMBL22557047 | 0.79 | TSHR (0.50) | TDP1GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110136944-A1 | COPOLYMERS BASED ON UNSATURATED MONO- OR DICARBOXYLIC ACID DERIVATIVES AND OXYALKYLENEGLYCOL-ALKENYL ETHERS, PROCESSES FOR THE PRODUCTION AND USE THEREOF | EVONIK DEGUSSA GMBH (DE) | 2011-06-09 | — | — | US | disclosed |
| EP-1981824-A2 | DISPERSION COMPRISING TITANIUM DIOXIDE AND POLYCARBOXYLATE ETHER | Evonik Degussa GmbH (DE) | 2008-10-22 | — | — | EP | disclosed |
| EP-1981823-A1 | DISPERSION COMPRISING SILICON DIOXIDE AND POLYCARBOXYLATE ETHER | Evonik Degussa GmbH (DE) | 2008-10-22 | — | — | EP | disclosed |
| US-7317062-B2 | Copolymers, preparation thereof and use as wetting agents and dispersants | BYK-CHEMIE GMBH (DE) | 2008-01-08 | — | — | US | disclosed |
| WO-2007088111-A1 | DISPERSION COMPRISING SILICON DIOXIDE AND POLYCARBOXYLATE ETHER | EVONIK DEGUSSA GMBH (DE) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007088110-A2 | DISPERSION COMPRISING TITANIUM DIOXIDE AND POLYCARBOXYLATE ETHER | EVONIK DEGUSSA GMBH (DE) | 2007-08-09 | — | — | WO | disclosed |
| US-20070161724-A1 | Copolymers based on unsaturated mono-or dicarboxylic acid derivatives and oxyalkyleneglycol-alkenyl ethers, method for the production and use thereof | EVONIK DEGUSSA GMBH (DE) | 2007-07-12 | — | — | US | disclosed |
| US-20060069224-A1 | Copolymers, preparation thereof and use as wetting agents and dispersants | BYK-CHEMIE GMBH (DE) | 2006-03-30 | — | — | US | disclosed |