Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.44 |
| ▸ | GABRE | P78334 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9362830 | 1.00 | TDP1 (0.56) | TDP1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL1043268 | 1.00 | TDP1 (0.56) | TDP1TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL29843257 | 1.00 | TDP1 (0.56) | TDP1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL27471991 | 1.00 | TDP1 (0.56) | TDP1TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL28454524 | 0.95 | TDP1 (0.50) | TDP1TSHRTP53EGLN1EGLN3 | |
| Propylene Glycol SCHEMBL1930686 | 0.89 | TDP1 (0.43) | TDP1TSHRTP53EGLN1EGLN3 | |
| Propylene Glycol SCHEMBL27851898 | 0.89 | TDP1 (0.43) | TDP1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL11877815 | 0.87 | TDP1 (0.42) | TDP1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL11114498 | 0.83 | TSHR (0.56) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7022069 | 0.83 | TSHR (0.50) | TDP1TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990397-A | High impact strength | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1991-02-05 | — | — | US | disclosed |
| US-4943474-A | CIRCUIT BOARDS, MIXTURE OF HARD AND SOFT POLYMERS | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-07-24 | — | — | US | disclosed |
| EP-0377769-A1 | Unsaturated polyester resin compositions and electrical laminates made therefrom | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-07-18 | — | — | EP | disclosed |