Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | APP | P05067 | 3/20 | 0.50 |
| ▸ | SNCA | P37840 | 3/20 | 0.50 |
| ▸ | BRD4 | O60885 | 8/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19308157 | 0.89 | BRD4 (0.52) | MAPTAPPSNCABRD4NPSR1 | |
| SCHEMBL19297710 | 0.89 | BRD4 (0.49) | MAPTAPPSNCABRD4NPSR1 | |
| SCHEMBL19297709 | 0.89 | BRD4 (0.49) | MAPTAPPSNCABRD4NPSR1 | |
| SCHEMBL19297708 | 0.89 | BRD4 (0.49) | MAPTAPPSNCABRD4NPSR1 | |
| SCHEMBL19308146 | 0.85 | CYP1B1 (0.38) | MAPTAPPSNCABRD4ALDH1A1 | |
| SCHEMBL21993899 | 0.82 | MAPT (0.51) | MAPTAPPSNCABRD4NPSR1 | |
| SCHEMBL19309425 | 0.80 | KDM4E (0.41) | MAPTAPPSNCABRD4NPSR1 | |
| SCHEMBL2473625 | 0.77 | CASP3 (0.61) | MAPTAPPSNCABRD4NPSR1 | |
| SCHEMBL8300613 | 0.76 | BRD4 (0.60) | MAPTAPPSNCABRD4ALDH1A1 | |
| SCHEMBL8791147 | 0.76 | BRD4 (0.64) | MAPTAPPSNCABRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751896-B1 | Asymmetric 7-N isatin dimer Schiff base compounds with antitumor activities and a method of preparing the same | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-09-05 | — | — | US | disclosed |
| US-9751896-B1 | Asymmetric 7-N isatin dimer Schiff base compounds with antitumor activities and a method of preparing the same | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-09-05 | — | — | US | disclosed |