Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.48 |
| ▸ | PRKDC | P78527 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.48 |
| ▸ | ATR | Q13535 | 5/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LDHB | P07195 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19413037 | 0.86 | KDM1A (0.52) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL15308592 | 0.83 | TYRO3 (0.50) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL19309166 | 0.83 | NPSR1 (0.53) | PIK3CDPIK3CAPIK3CGPIK3CBGSK3B | |
| SCHEMBL16628998 | 0.80 | ATR (0.49) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL17718279 | 0.80 | TYRO3 (0.52) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL19309168 | 0.79 | TYRO3 (0.67) | PIK3CDPIK3CAPIK3CGPRKDCABL1 | |
| SCHEMBL21074248 | 0.76 | CDK8 (0.53) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL29709318 | 0.76 | CDK8 (0.53) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL19309167 | 0.76 | ATR (0.54) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL28196773 | 0.74 | NPC1 (0.61) | CDK8CA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751888-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | disclosed |