Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 4/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.48 |
| ▸ | PRKDC | P78527 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 6/20 | 0.43 |
| ▸ | CA2 | P00918 | 6/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17657921 | 0.85 | ALDH1A1 (0.50) | ATRTYRO3PRKDCATMPIK3CD | |
| SCHEMBL17657856 | 0.84 | PIK3CD (0.53) | ATRTYRO3PRKDCATMPIK3CD | |
| SCHEMBL15308592 | 0.83 | TYRO3 (0.50) | ATRCDK8TYRO3PRKDCATM | |
| SCHEMBL16628980 | 0.81 | NPSR1 (0.53) | — | |
| SCHEMBL16629017 | 0.81 | JAK2 (0.55) | ATRTYRO3PRKDCATMPIK3CD | |
| SCHEMBL17657923 | 0.81 | BRD4 (0.49) | TYRO3PIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL17657874 | 0.81 | PIK3CD (0.48) | ATRTYRO3PRKDCATMPIK3CD | |
| SCHEMBL17718279 | 0.80 | TYRO3 (0.52) | ATRCDK8TYRO3PRKDCATM | |
| SCHEMBL19309232 | 0.80 | PIK3CD (0.48) | ATRCDK8TYRO3PRKDCATM | |
| SCHEMBL28196773 | 0.77 | NPC1 (0.61) | CDK8CA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015143012-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF PI3K-GAMMA MEDIATED DISORDERS | INFINITY PHARMACEUTICALS, INC. (US) | 2015-09-24 | — | — | WO | disclosed |
| WO-2015051241-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2015-04-09 | — | — | WO | disclosed |