Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.47 |
| ▸ | TNF | P01375 | 3/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 12/20 | 0.41 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.41 |
| ▸ | IL1B | P01584 | 2/20 | 0.41 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19309918 | 0.90 | CRBN (0.44) | CRBNTNFDDB1IKZF3IL1B | |
| SCHEMBL22199317 | 0.81 | CRBN (0.43) | CRBNTNFDDB1IKZF3IL1B | |
| SCHEMBL22199374 | 0.81 | CRBN (0.44) | CRBNTNFDDB1IKZF3IL1B | |
| SCHEMBL21924013 | 0.72 | — | — | |
| SCHEMBL21281321 | 0.71 | CRBN (0.50) | CRBNTNFDDB1IKZF3IL1B | |
| SCHEMBL21927071 | 0.71 | — | — | |
| SCHEMBL19310127 | 0.71 | — | — | |
| SCHEMBL23864613 | 0.69 | CRBN (0.62) | CRBNTNFDDB1IKZF3IL1B | |
| SCHEMBL19310202 | 0.68 | — | — | |
| SCHEMBL22199259 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643709-A1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Kangpu Biopharmaceuticals, Ltd. (CN) | 2020-04-29 | — | — | EP | disclosed |
| EP-3527210-A1 | COMPOSITION, APPLICATION THEREOF AND TREATMENT METHOD | Kangpu Biopharmaceuticals, Ltd. (CN) | 2019-08-21 | — | — | EP | disclosed |
| EP-3214081-A1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Kangpu Biopharmaceuticals, Ltd. (CN) | 2017-09-06 | — | — | EP | disclosed |