Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | HTR2B | P41595 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1276464 | 0.82 | CYP1A2 (0.56) | HTR2ASIGMAR1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL5243364 | 0.79 | NPSR1 (0.53) | HTR2ASIGMAR1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL12267719 | 0.77 | NPSR1 (0.47) | HTR2ASIGMAR1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL20438072 | 0.77 | HTR2A (0.53) | HTR2ASIGMAR1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL2566639 | 0.74 | HTR2A (0.70) | HTR2ASIGMAR1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL8349426 | 0.74 | CYP2C19 (0.52) | HTR2ASIGMAR1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL19359277 | 0.73 | MMP2 (0.61) | HTR2ASIGMAR1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL13259162 | 0.73 | KDM4E (0.51) | HTR2ASIGMAR1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL20729394 | 0.73 | HTR2A (0.49) | HTR2ASIGMAR1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL21214839 | 0.73 | GRM5 (0.36) | HTR2ASIGMAR1HTR2CHTR2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170253601-A1 | Substituted Pyrrolidine Compounds | Epizyme, Inc. (US) | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170253601-A1 | Substituted Pyrrolidine Compounds | SMYD2, SMYD3, SNRPD2 | HTR2A 3159/4885SIGMAR1 538/4885NPSR1 2831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.