Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.74 |
| ▸ | RAB9A | P51151 | 7/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | POLB | P06746 | 3/20 | 0.74 |
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | APP | P05067 | 4/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.60 |
| ▸ | CLK1 | P49759 | 4/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1691332 | 0.86 | DYRK1A (0.60) | NPC1RAB9AALDH1A1KDM4EPOLB | |
| SCHEMBL1691270 | 0.86 | NR4A2 (0.71) | NPC1RAB9AALDH1A1KDM4EPOLB | |
| SCHEMBL31460615 | 0.85 | ALDH1A1 (0.60) | NPC1RAB9AALDH1A1KDM4EPOLB | |
| SCHEMBL2126735 | 0.82 | NPC1 (0.72) | NPC1RAB9AALDH1A1KDM4EPOLB | |
| SCHEMBL1691265 | 0.82 | NR4A2 (0.57) | NPC1RAB9AALDH1A1KDM4EPOLB | |
| Bromide SCHEMBL1691882 | 0.81 | NPC1 (0.70) | NPC1RAB9AALDH1A1KDM4EPOLB | |
| SCHEMBL5305546 | 0.80 | NR4A2 (0.55) | NPC1RAB9AALDH1A1KDM4EPOLB | |
| SCHEMBL7605200 | 0.80 | NPC1 (0.77) | NPC1RAB9AALDH1A1KDM4EPOLB | |
| Bromide SCHEMBL1691457 | 0.78 | NPC1 (0.75) | NPC1RAB9AALDH1A1KDM4EPOLB | |
| SCHEMBL4157927 | 0.77 | NPC1 (0.69) | NPC1RAB9AALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370373-B2 | Antitumor derivatives for differentiation therapy | THE CLEVELAND CLINIC FOUNDATION (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180194764-A1 | ANTITUMOR DERIVATIVES FOR DIFFERENTIATION THERAPY | CLEVELAND CLINIC FOUND (US) | 2018-07-12 | — | — | US | disclosed |
| US-9926316-B2 | Antitumor derivatives for differentiation therapy | THE CLEVELAND CLINIC FOUNDATION (US) | 2018-03-27 | — | — | US | disclosed |
| US-20170253589-A1 | ANTITUMOR DERIVATIVES FOR DIFFERENTIATION THERAPY | THE CLEVELAND CLINIC FOUNDATION | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194764-A1 | ANTITUMOR DERIVATIVES FOR DIFFERENTIATION THERAPY | MYD88, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS | NPC1 3167/4885RAB9A 1723/4885ALDH1A1 3309/4885 |
| US-20170253589-A1 | ANTITUMOR DERIVATIVES FOR DIFFERENTIATION THERAPY | MYD88, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS | NPC1 3167/4885RAB9A 1723/4885ALDH1A1 3309/4885 |
| US-10370373-B2 | Antitumor derivatives for differentiation therapy | MYD88, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS | NPC1 3167/4885RAB9A 1723/4885ALDH1A1 3309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.