Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.37 |
| ▸ | ITGAL | P20701 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201730 | 0.88 | HRH4 (0.51) | MEN1KMT2AHRH4ALDH1A1LRRK2 | |
| SCHEMBL18931264 | 0.87 | PIK3CA (0.51) | MEN1KMT2AALDH1A1LRRK2PIK3CA | |
| SCHEMBL2737324 | 0.83 | HRH4 (0.51) | MEN1KMT2AHRH4LRRK2ITGB2 | |
| SCHEMBL11951622 | 0.82 | HRH4 (0.54) | HRH4ALDH1A1LRRK2NMT1ITGB2 | |
| SCHEMBL4547903 | 0.80 | HRH4 (0.47) | MEN1KMT2AHRH4LRRK2ITGB2 | |
| SCHEMBL16019498 | 0.76 | PANK3 (0.48) | MEN1KMT2AHRH4ITGB2ICAM1 | |
| SCHEMBL18924652 | 0.76 | MEN1 (0.48) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL18930172 | 0.75 | MEN1 (0.47) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL24652016 | 0.74 | HRH4 (0.52) | HRH4ALDH1A1LRRK2KDM4E | |
| SCHEMBL15341762 | 0.74 | LRRK2 (0.42) | MEN1KMT2AHRH4LRRK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834513-B2 | Benzylamine derivatives | Kalvista Pharmceuticals Limited (GB) | 2017-12-05 | — | — | US | disclosed |
| US-20170253561-A1 | Benzylamine Derivatives | KALVISTA PHARMACEUTICALS LTD (GB) | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170253561-A1 | Benzylamine Derivatives | BDKRB1, BDKRB2, KLKB1 | MEN1 766/4885KMT2A 492/4885HRH4 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.