Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylpyrrolidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.65 |
| ▸ | BRD2 | P25440 | 1/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylpyrrolidone SCHEMBL28293219 | 0.89 | BRD4 (0.52) | BRD4BRD2PIK3CDLMNACA12 | |
| Methylpyrrolidone SCHEMBL10787779 | 0.89 | BRD4 (0.65) | BRD4BRD2PIK3CDLMNACA12 | |
| Methylpyrrolidone SCHEMBL15441681 | 0.89 | BRD4 (0.65) | BRD4BRD2PIK3CDLMNACA12 | |
| Methylpyrrolidone SCHEMBL3004368 | 0.88 | BRD4 (0.77) | BRD4BRD2PIK3CDLMNACA12 | |
| Methylpyrrolidone SCHEMBL9653445 | 0.84 | BRD4 (0.50) | BRD4BRD2PIK3CDLMNATDP1 | |
| Methylpyrrolidone SCHEMBL8469798 | 0.84 | BRD4 (0.59) | BRD4BRD2PIK3CDLMNACA12 | |
| Methylpyrrolidone SCHEMBL1841013 | 0.84 | BRD4 (0.77) | BRD4BRD2PIK3CDLMNACA12 | |
| Methylpyrrolidone SCHEMBL3802011 | 0.84 | BRD4 (0.77) | BRD4BRD2PIK3CDLMNACA12 | |
| Methylpyrrolidone SCHEMBL28287420 | 0.82 | BRD4 (0.57) | BRD4BRD2PIK3CDLMNACA12 | |
| Methylpyrrolidone SCHEMBL9815876 | 0.82 | BRD4 (0.74) | BRD4BRD2PIK3CDLMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117511567-A | Liquid crystal aligning agent, liquid crystal alignment film and liquid crystal display element | 日产化学株式会社 | 2024-02-06 | — | — | CN | disclosed |
| CN-111826242-A | Cleaning solution, method of cleaning semiconductor substrate, and method of manufacturing semiconductor device | 台湾积体电路制造股份有限公司 | 2020-10-27 | — | — | CN | disclosed |
| EP-3720420-A1 | INJECTABLE LONG-ACTING LOCAL ANESTHETIC SEMI-SOLID GEL FORMULATIONS | Huzhou Hui Zhong Ji Shi Biotechnology Co., Ltd. (CN) | 2020-10-14 | — | — | EP | disclosed |
| US-10561606-B2 | Injectable long-acting local anesthetic semi-solid gel formulations | MIRA PHARMA CORPORATION (US) | 2020-02-18 | — | — | US | disclosed |
| CN-106029729-B | The coating composition of two aspartates comprising diisocyanate chain extension | 涂层国外知识产权有限公司 | 2019-11-08 | — | — | CN | disclosed |
| CN-106029728-B | The coating composition of two aspartates comprising diisocyanate chain extension | 涂层国外知识产权有限公司 | 2019-08-06 | — | — | CN | disclosed |
| WO-2019113366-A1 | INJECTABLE LONG-ACTING LOCAL ANESTHETIC SEMI-SOLID GEL FORMULATIONS | MIRA PHARMA CORPORATION (US) | 2019-06-13 | — | — | WO | disclosed |
| US-20190167574-A1 | INJECTABLE LONG-ACTING LOCAL ANESTHETIC SEMI-SOLID GEL FORMULATIONS | HUZHOU HUI ZHONG JI SHI BIOTECHNOLOGY CO., LTD (CN) | 2019-06-06 | — | — | US | disclosed |
| CN-106459453-A | Resin-containing sheet, and structure and circuit board using same | 太阳控股株式会社 | 2017-02-22 | — | — | CN | disclosed |
| CN-106029728-A | Coating compositions comprising diisocyanate chain extended bisaspartates | 涂层国外知识产权有限公司 | 2016-10-12 | — | — | CN | disclosed |
| EP-1131062-A4 | INJECTABLE PROPOFOL FORMULATIONS | VETERINARY RES ASSOCIATES INC (US) | 2002-07-03 | — | — | EP | disclosed |
| EP-1131062-A1 | INJECTABLE PROPOFOL FORMULATIONS | Veterinary Research Associates, Inc. (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1131062-A1 | INJECTABLE PROPOFOL FORMULATIONS | Veterinary Research Associates, Inc. (US) | 2001-09-12 | — | — | EP | disclosed |
| US-6071933-A | Homogeneous remifentanil-propofol blend for patient controlled anesthesia and process for its use | DIVERSIFIED MEDICAL INNOVATIONS, INC. (CA) | 2000-06-06 | — | — | US | disclosed |
| WO-2000006142-A1 | INJECTABLE PROPOFOL FORMULATIONS | VETERINARY RESEARCH ASSOCIATES (US) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006142-A1 | INJECTABLE PROPOFOL FORMULATIONS | VETERINARY RESEARCH ASSOCIATES (US) | 2000-02-10 | — | — | WO | disclosed |
| US-5962536-A | USING N-METHYLPYRROLIDONE OR 2-PYRROLIDONE AS SOLVENT | VETERINARY RESEARCH ASSOCIATES, INC. | 1999-10-05 | — | — | US | disclosed |
| US-5962536-A | USING N-METHYLPYRROLIDONE OR 2-PYRROLIDONE AS SOLVENT | VETERINARY RESEARCH ASSOCIATES, INC. | 1999-10-05 | — | — | US | disclosed |
| US-5773422-A | Avermectin formulation | VETERINARY RESEARCH ASSOCIATES, INC. | 1998-06-30 | — | — | US | disclosed |
| WO-1997026895-A1 | AVERMECTIN FORMULATION | KOMER GENE (US) | 1997-07-31 | — | — | WO | disclosed |