Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL86605 | 0.90 | KDM4E (0.41) | PTAFRMAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21096736 | 0.87 | MAPT (0.40) | PTAFRMAPTMEN1KMT2AKDR | |
| SCHEMBL83347 | 0.85 | MAPT (0.50) | MAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL82489 | 0.84 | CCNC (0.39) | PTAFRMAPTMEN1KMT2AHPGDS | |
| SCHEMBL29475025 | 0.84 | CCNC (0.39) | PTAFRMAPTMEN1KMT2AHPGDS | |
| SCHEMBL19346312 | 0.83 | MAPT (0.34) | PTAFRMAPTMEN1KMT2APDGFRB | |
| SCHEMBL17727593 | 0.82 | MAPT (0.36) | PTAFRMAPTMEN1KMT2AKDR | |
| SCHEMBL22864303 | 0.82 | MAPT (0.36) | PTAFRMAPTMEN1KMT2AKDR | |
| SCHEMBL86828 | 0.82 | KMT2A (0.40) | MAPTMEN1KMT2AHPGDPOLB | |
| SCHEMBL87060 | 0.81 | POLB (0.40) | MAPTMEN1KMT2AKDRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426657-B1 | 2 AMINO N [7 METHOXY 2, 3-DIHYDROIMIDAZO-[1, 2-C]QUINAZOLIN-5-YL]PYRIMIDINE 5 CARBOXAMIDES | Bayer Pharma AG (DE) | 2022-07-13 | — | — | EP | disclosed |
| EP-3426657-B1 | 2 AMINO N [7 METHOXY 2, 3-DIHYDROIMIDAZO-[1, 2-C]QUINAZOLIN-5-YL]PYRIMIDINE 5 CARBOXAMIDES | Bayer Pharma AG (DE) | 2022-07-13 | — | — | EP | disclosed |
| CN-108884098-B | 2-amino-N- [ 7-methoxy-2, 3-dihydroimidazo [1,2-c ] quinazolin-5-yl ] pyrimidine-5-carboxamides | 拜耳制药股份公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-108884098-B | 2-amino-N- [ 7-methoxy-2, 3-dihydroimidazo [1,2-c ] quinazolin-5-yl ] pyrimidine-5-carboxamides | 拜耳制药股份公司 | 2021-09-14 | — | — | CN | disclosed |
| US-10844066-B2 | 2-amino-N-[7-methoxy-2, 3-dihydroimidazo-[1,2-c] quinazolin-5-yl] pyrimidine-5-carboxamides | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-11-24 | — | — | US | disclosed |
| US-10844066-B2 | 2-amino-N-[7-methoxy-2, 3-dihydroimidazo-[1,2-c] quinazolin-5-yl] pyrimidine-5-carboxamides | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-11-24 | — | — | US | disclosed |
| US-20190092775-A1 | 2-AMINO-N- [7-METHOXY-2, 3-DIHYDROIMIDAZO-[1, 2-C] QUINAZOLIN-5-YL] PYRIMIDINE-5-CARBOXAMIDES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-03-28 | — | — | US | disclosed |
| US-20190092775-A1 | 2-AMINO-N- [7-METHOXY-2, 3-DIHYDROIMIDAZO-[1, 2-C] QUINAZOLIN-5-YL] PYRIMIDINE-5-CARBOXAMIDES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-03-28 | — | — | US | disclosed |
| EP-3426657-A1 | 2 AMINO N [7 METHOXY 2, 3-DIHYDROIMIDAZO-[1, 2-C]QUINAZOLIN-5-YL]PYRIMIDINE 5 CARBOXAMIDES | Bayer Pharma Aktiengesellschaft (DE) | 2019-01-16 | — | — | EP | disclosed |
| EP-3426657-A1 | 2 AMINO N [7 METHOXY 2, 3-DIHYDROIMIDAZO-[1, 2-C]QUINAZOLIN-5-YL]PYRIMIDINE 5 CARBOXAMIDES | Bayer Pharma Aktiengesellschaft (DE) | 2019-01-16 | — | — | EP | disclosed |
| WO-2017153220-A1 | 2—AMINO—N— [7—METHOXY—2, 3-DIHYDROIMIDAZO-[1, 2-C] QUINAZOLIN-5-YL] PYRIMIDINE—5—CARBOXAMIDES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-14 | — | — | WO | disclosed |
| WO-2017153220-A1 | 2—AMINO—N— [7—METHOXY—2, 3-DIHYDROIMIDAZO-[1, 2-C] QUINAZOLIN-5-YL] PYRIMIDINE—5—CARBOXAMIDES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844066-B2 | 2-amino-N-[7-methoxy-2, 3-dihydroimidazo-[1,2-c] quinazolin-5-yl] pyrimidine-5-carboxamides | PIK3CA, PIK3CD, PIK3CB | PTAFR 550/4885MAPT 3263/4885SLC6A2 4508/4885 |
| US-20190092775-A1 | 2-AMINO-N- [7-METHOXY-2, 3-DIHYDROIMIDAZO-[1, 2-C] QUINAZOLIN-5-YL] PYRIMIDINE-5-CARBOXAMIDES | PIK3CA, PIK3CD, PIK3CB | PTAFR 550/4885MAPT 3263/4885SLC6A2 4508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.