Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PTAFR | P25105 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17727593 | 0.93 | MAPT (0.36) | MAPTP4HTMSMN1; SMN2THRBPOLB | |
| SCHEMBL22864303 | 0.92 | MAPT (0.36) | MAPTP4HTMSMN1; SMN2THRBPOLB | |
| SCHEMBL19346312 | 0.90 | MAPT (0.34) | MAPTP4HTMSMN1; SMN2THRBPOLB | |
| SCHEMBL21096738 | 0.90 | MAPT (0.35) | MAPTP4HTMSMN1; SMN2POLBPTAFR | |
| SCHEMBL19328941 | 0.90 | TEK (0.34) | MAPTP4HTMMEN1KMT2ACSF1R | |
| SCHEMBL1655754 | 0.89 | MAPT (0.34) | MAPTMEN1KMT2AKDR | |
| SCHEMBL21096837 | 0.89 | MAPT (0.34) | MAPTSMN1; SMN2 | |
| SCHEMBL29475091 | 0.89 | MAPT (0.34) | MAPTMEN1KMT2AKDR | |
| SCHEMBL19328940 | 0.89 | CSNK2A2 (0.37) | THRBPTAFRMEN1KMT2AHDAC1 | |
| SCHEMBL19328643 | 0.87 | PTAFR (0.37) | MAPTP4HTMSMN1; SMN2THRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021202830-A2 | HSP90-BINDING CONJUGATES AND FORMULATIONS THEREOF | TARVEDA THERAPEUTICS, INC. (US) | 2021-10-07 | — | — | WO | disclosed |
| WO-2019118830-A1 | HSP90-TARGETING CONJUGATES AND FORMULATIONS THEREOF | TARVEDA THERAPEUTICS, INC. (US) | 2019-06-20 | — | — | WO | disclosed |