Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | STS | P08842 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | CTSE | P14091 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19331914 | 0.91 | EPHX2 (0.46) | EPHX2STSMAPTALDH1A1TSHR | |
| SCHEMBL4732973 | 0.81 | EPHX2 (0.61) | EPHX2STSMAPTALDH1A1TSHR | |
| SCHEMBL16111394 | 0.81 | EPHX2 (0.44) | EPHX2STSMAPTALDH1A1TSHR | |
| SCHEMBL28611807 | 0.80 | ALDH1A1 (0.54) | EPHX2STSMAPTALDH1A1TSHR | |
| SCHEMBL27415157 | 0.80 | ALDH1A1 (0.54) | EPHX2STSMAPTALDH1A1TSHR | |
| SCHEMBL27415267 | 0.77 | EPHX2 (0.46) | EPHX2STSMAPTALDH1A1TSHR | |
| SCHEMBL21577641 | 0.77 | EPHX2 (0.57) | EPHX2STSMAPTALDH1A1MEN1 | |
| SCHEMBL18656011 | 0.76 | EPHX2 (0.49) | EPHX2STSMAPTALDH1A1TSHR | |
| SCHEMBL19331898 | 0.75 | TSHR (0.40) | ALDH1A1TSHRMEN1KMT2AS1PR1 | |
| SCHEMBL27415228 | 0.75 | TSHR (0.55) | EPHX2STSMAPTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156177-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |
| WO-2017156177-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |