Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19333383 | 0.87 | TDP1 (0.44) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL19333396 | 0.85 | TDP1 (0.42) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL10261336 | 0.82 | MAPT (0.57) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL17917638 | 0.81 | TDP1 (0.53) | MAPTSMN1; SMN2LIN28ATDP1CYP1A2 | |
| SCHEMBL17914541 | 0.81 | KCNA5 (0.58) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL22458614 | 0.80 | TDP1 (0.51) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL15695403 | 0.80 | TDP1 (0.71) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL12088818 | 0.78 | SMN1; SMN2 (0.52) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL12089203 | 0.76 | MAPT (0.50) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL7095634 | 0.76 | TDP1 (0.57) | MAPTSMN1; SMN2LIN28ATDP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9758492-B2 | IDO inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-12 | — | — | US | disclosed |