Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19333383 | 0.90 | TDP1 (0.44) | TDP1MAPTSMN1; SMN2LIN28ANR1H2 | |
| SCHEMBL19333382 | 0.85 | MAPT (0.47) | TDP1MAPTSMN1; SMN2LIN28ANR1H2 | |
| SCHEMBL17917638 | 0.76 | TDP1 (0.53) | TDP1MAPTSMN1; SMN2LIN28ANR1H2 | |
| SCHEMBL170856 | 0.75 | TDP1 (0.47) | TDP1MAPTSMN1; SMN2LIN28ACYP1A2 | |
| SCHEMBL17914541 | 0.73 | KCNA5 (0.58) | TDP1MAPTSMN1; SMN2LIN28ANR1H2 | |
| SCHEMBL13263966 | 0.73 | TDP1 (0.52) | TDP1MAPTSMN1; SMN2LIN28ANR1H2 | |
| SCHEMBL13999364 | 0.72 | TSHR (0.50) | TDP1MAPTSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL7095634 | 0.70 | TDP1 (0.57) | TDP1MAPTSMN1; SMN2LIN28ACYP1A2 | |
| SCHEMBL10261336 | 0.70 | MAPT (0.57) | TDP1MAPTSMN1; SMN2LIN28ACYP1A2 | |
| SCHEMBL12088818 | 0.70 | SMN1; SMN2 (0.52) | TDP1MAPTSMN1; SMN2LIN28ANR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9758492-B2 | IDO inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-12 | — | — | US | disclosed |