Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.84 |
| ▸ | HTT | P42858 | 8/20 | 0.84 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.84 |
| ▸ | LMNA | P02545 | 4/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.47 |
| ▸ | MEN1 | O00255 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15679885 | 0.91 | KDM4E (1.00) | KDM4EHTTL3MBTL1LMNACYP1A2 | |
| SCHEMBL19334358 | 0.85 | KDM4E (0.62) | KDM4EHTTL3MBTL1LMNACYP1A2 | |
| SCHEMBL19334446 | 0.84 | KDM4E (0.83) | KDM4EHTTL3MBTL1LMNACYP1A2 | |
| SCHEMBL19334538 | 0.83 | KDM4E (0.67) | KDM4EHTTL3MBTL1LMNACYP1A2 | |
| SCHEMBL17232446 | 0.79 | KDM4E (0.72) | KDM4EHTTL3MBTL1LMNACYP1A2 | |
| SCHEMBL19334338 | 0.77 | L3MBTL1 (0.58) | KDM4EHTTL3MBTL1LMNACYP1A2 | |
| SCHEMBL13401499 | 0.77 | KDM4E (0.75) | KDM4EHTTL3MBTL1LMNACYP1A2 | |
| SCHEMBL19334422 | 0.76 | KDM4E (0.62) | KDM4EHTTL3MBTL1LMNACYP1A2 | |
| SCHEMBL15679880 | 0.75 | KDM4E (0.67) | KDM4EHTTL3MBTL1LMNACYP1A2 | |
| SCHEMBL14958575 | 0.75 | KDM4E (1.00) | KDM4EHTTL3MBTL1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |