Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 10/20 | 0.80 |
| ▸ | MEN1 | O00255 | 7/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.80 |
| ▸ | MAX | P61244 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.46 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13401376 | 0.89 | MYC (1.00) | MYCMEN1KMT2AMAXPOLB | |
| SCHEMBL17934450 | 0.78 | MYC (0.80) | MYCMEN1KMT2AMAXPOLB | |
| SCHEMBL17927364 | 0.74 | MYC (0.72) | MYCMEN1KMT2AMAXPOLB | |
| SCHEMBL17927368 | 0.74 | MYC (0.72) | MYCMEN1KMT2AMAXPOLB | |
| SCHEMBL19334344 | 0.72 | IDO1 (0.76) | MYCMEN1KMT2AMAXPOLB | |
| SCHEMBL17927401 | 0.72 | MYC (0.69) | MYCMEN1KMT2AMAXPOLB | |
| SCHEMBL355549 | 0.72 | FABP4 (0.80) | MEN1KMT2AUSP2RECQLFABP4 | |
| SCHEMBL30320327 | 0.72 | FABP4 (0.80) | MEN1KMT2AUSP2RECQLFABP4 | |
| SCHEMBL2464366 | 0.71 | MEN1 (1.00) | MYCMEN1KMT2AMAXPOLB | |
| SCHEMBL16107852 | 0.71 | MEN1 (0.72) | MYCMEN1KMT2AMAXPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |