Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | HTT | P42858 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 9/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | GRK2 | P25098 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.45 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LIG1 | P18858 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14959214 | 0.87 | MAPT (0.59) | MAPTALDH1A1HTTSMN1; SMN2TDP1 | |
| SCHEMBL13401808 | 0.85 | MAPT (0.57) | MAPTALDH1A1HTTSMN1; SMN2TDP1 | |
| SCHEMBL13401793 | 0.80 | MEN1 (0.67) | MAPTALDH1A1HTTSMN1; SMN2TDP1 | |
| SCHEMBL12648536 | 0.76 | CFTR (0.67) | MAPTALDH1A1HTTSMN1; SMN2TDP1 | |
| SCHEMBL19334390 | 0.75 | MEN1 (0.58) | MAPTALDH1A1HTTSMN1; SMN2TDP1 | |
| SCHEMBL14082236 | 0.75 | MAPT (0.58) | MAPTALDH1A1HTTSMN1; SMN2TDP1 | |
| SCHEMBL16211083 | 0.72 | KDM4E (0.67) | MAPTALDH1A1HTTSMN1; SMN2TDP1 | |
| SCHEMBL16211082 | 0.72 | KDM4E (0.67) | MAPTALDH1A1HTTSMN1; SMN2TDP1 | |
| SCHEMBL5363022 | 0.72 | MAPT (0.56) | MAPTALDH1A1HTTSMN1; SMN2TDP1 | |
| SCHEMBL5363026 | 0.72 | MAPT (0.56) | MAPTALDH1A1HTTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |