Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19337104 | 0.89 | EGFR (0.54) | EGFRMKNK2MKNK1KDRCCNT1 | |
| SCHEMBL30467909 | 0.89 | EGFR (0.54) | EGFRMKNK2MKNK1KDRCCNT1 | |
| SCHEMBL19337193 | 0.86 | EGFR (0.58) | EGFRKDR | |
| SCHEMBL19707904 | 0.86 | EGFR (0.43) | EGFRMKNK2MKNK1KDR | |
| SCHEMBL20610525 | 0.86 | EGFR (0.46) | EGFRMKNK2MKNK1KDRMEN1 | |
| SCHEMBL28392219 | 0.86 | EGFR (0.46) | EGFRMKNK2MKNK1KDRCCNT1 | |
| SCHEMBL21265492 | 0.85 | CCNT1 (0.46) | EGFRMKNK2MKNK1KDRCCNT1 | |
| SCHEMBL30647338 | 0.85 | CCNT1 (0.46) | EGFRMKNK2MKNK1KDRCCNT1 | |
| SCHEMBL19337070 | 0.85 | EGFR (0.43) | EGFRMKNK2MKNK1KDRCCNT1 | |
| SCHEMBL19089467 | 0.83 | KDR (0.44) | EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3216786-A1 | PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF | Shanghai Shaletech Technology Co., Ltd. (CN) | 2017-09-13 | — | — | EP | disclosed |