Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 9/20 | 0.41 |
| ▸ | CTSD | P07339 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1934139 | 0.90 | BACE1 (0.38) | BACE1BACE2 | |
| SCHEMBL1934848 | 0.85 | BACE1 (0.50) | BACE1BACE2 | |
| SCHEMBL3300948 | 0.85 | BACE1 (0.51) | BACE1BACE2CTSD | |
| SCHEMBL1934147 | 0.81 | BACE1 (0.36) | BACE1BACE2 | |
| SCHEMBL1933735 | 0.79 | BACE1 (0.48) | BACE1BACE2CTSD | |
| SCHEMBL13391488 | 0.79 | BACE1 (0.48) | BACE1BACE2CTSD | |
| SCHEMBL7914943 | 0.79 | BACE1 (0.48) | BACE1BACE2CTSD | |
| SCHEMBL1934572 | 0.75 | BACE1 (0.46) | BACE1BACE2 | |
| SCHEMBL9888436 | 0.74 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL7924503 | 0.73 | BACE1 (0.69) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332943-A1 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2011-06-15 | — | — | EP | disclosed |