Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 12/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12129855 | 0.94 | SMO (0.78) | SMONPC1RAB9ANQO2CASP3 | |
| SCHEMBL12129883 | 0.84 | SMO (0.78) | SMONPC1RAB9ANQO2CASP3 | |
| SCHEMBL12129870 | 0.83 | SMO (0.83) | SMONPC1RAB9AALDH1A1CYP2C9 | |
| SCHEMBL1335388 | 0.83 | RAB9A (0.70) | SMONPC1RAB9ACASP3SENP7 | |
| SCHEMBL12129826 | 0.83 | SMO (0.83) | SMONPC1RAB9AALDH1A1CYP2C9 | |
| SCHEMBL29390703 | 0.82 | SMO (1.00) | SMONPC1RAB9AALDH1A1CYP2C9 | |
| SCHEMBL12129860 | 0.82 | SMO (1.00) | SMONPC1RAB9AALDH1A1CYP2C9 | |
| SCHEMBL8211832 | 0.82 | SMO (0.62) | SMONPC1RAB9ANQO2CASP3 | |
| SCHEMBL19337622 | 0.82 | SMO (0.82) | SMONPC1RAB9AALDH1A1CYP2C9 | |
| SCHEMBL12129833 | 0.82 | SMO (0.82) | SMONPC1RAB9ACASP3SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291352-B1 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NAT RECH SCIENT (FR) | 2017-09-13 | — | — | EP | disclosed |