Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA7 | P43166 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.35 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12775693 | 0.83 | POLB (0.43) | APLNRTDP1CA1CA7CA2 | |
| SCHEMBL17702010 | 0.80 | TDP1 (0.38) | APLNRTDP1CA1CA7CA2 | |
| SCHEMBL23331500 | 0.80 | TDP1 (0.38) | APLNRTDP1CA1CA7CA2 | |
| SCHEMBL22236476 | 0.79 | TDP1 (0.35) | APLNRTDP1CA1CA7CA2 | |
| SCHEMBL25247785 | 0.79 | TDP1 (0.40) | APLNRTDP1CA1CA7CA2 | |
| SCHEMBL1587141 | 0.79 | TDP1 (0.40) | APLNRTDP1CA1CA7CA2 | |
| SCHEMBL21261831 | 0.79 | TDP1 (0.42) | APLNRTDP1CA1CA7CA2 | |
| SCHEMBL24261262 | 0.78 | CA1 (0.43) | APLNRTDP1CA1CA7CA2 | |
| SCHEMBL19400336 | 0.78 | MAOA (0.39) | APLNRTDP1CA1CA7CA2 | |
| SCHEMBL17525437 | 0.78 | MEN1 (0.39) | APLNRTDP1CA1CA7CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621536-B1 | AMATOXIN-CONJUGATES | HEIDELBERG PHARMA GMBH (DE) | 2017-09-13 | — | — | EP | disclosed |