Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 8/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | INSR | P06213 | 2/20 | 0.60 |
| ▸ | FYN | P06241 | 2/20 | 0.60 |
| ▸ | YES1 | P07947 | 2/20 | 0.60 |
| ▸ | LYN | P07948 | 2/20 | 0.60 |
| ▸ | RET | P07949 | 2/20 | 0.60 |
| ▸ | MET | P08581 | 2/20 | 0.60 |
| ▸ | ROS1 | P08922 | 2/20 | 0.60 |
| ▸ | KIT | P10721 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | BRAF | P15056 | 2/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.60 |
| ▸ | FLT1 | P17948 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21862429 | 0.88 | LCK (0.58) | LCKFGFR3FGFR4ALKFGFR1 | |
| SCHEMBL27256691 | 0.87 | LCK (0.62) | LCKFGFR3FGFR4ALKFGFR1 | |
| SCHEMBL373634 | 0.84 | HCK (0.56) | LCKFGFR3FGFR4ALKFGFR1 | |
| SCHEMBL374708 | 0.84 | HCK (0.58) | LCKFGFR3FGFR4ALKFGFR1 | |
| SCHEMBL14660127 | 0.83 | CD274 (0.57) | LCKFGFR3FGFR4ALKFGFR1 | |
| SCHEMBL19848775 | 0.80 | HCK (0.55) | LCKFGFR3FGFR4ALKFGFR1 | |
| SCHEMBL22132803 | 0.76 | FGFR3 (0.72) | LCKFGFR3FGFR4ALKFGFR1 | |
| SCHEMBL18398033 | 0.76 | FGFR3 (0.85) | LCKFGFR3FGFR4ALKFGFR1 | |
| SCHEMBL19588439 | 0.76 | FGFR3 (0.77) | LCKFGFR3FGFR4ALKFGFR1 | |
| Infigratinib SCHEMBL374435 | 0.76 | FGFR3 (1.00) | LCKFGFR3FGFR4ALKFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3925622-A1 | COMBINATION THERAPIES | Novartis AG (CH) | 2021-12-22 | — | — | EP | disclosed |
| EP-3659621-A1 | COMBINATION THERAPIES FOR CANCER | Novartis AG (CH) | 2020-06-03 | — | — | EP | disclosed |
| EP-2902489-B9 | FGFR3 FUSION GENE AND PHARMACEUTICAL DRUG TARGETING SAME | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-02-07 | — | — | EP | disclosed |
| EP-2902489-B1 | FGFR3 FUSION GENE AND PHARMACEUTICAL DRUG TARGETING SAME | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-09-13 | — | — | EP | disclosed |