Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19339655 | 0.87 | PREP (0.37) | PREPMEN1KMT2APDE4APDE4B | |
| SCHEMBL9977159 | 0.87 | PREP (0.42) | PREPMEN1KMT2AKDM4EMAPT | |
| SCHEMBL15368133 | 0.87 | PREP (0.42) | PREPMEN1KMT2AKDM4EMAPT | |
| SCHEMBL17656300 | 0.87 | PREP (0.41) | PREPMEN1KMT2APDE4APDE4B | |
| SCHEMBL2708422 | 0.82 | PREP (0.41) | PREPMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL202883 | 0.82 | PREP (0.41) | PREPMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL18462482 | 0.82 | PREP (0.41) | PREPMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL16891276 | 0.76 | PREP (0.43) | PREPMEN1KMT2APDE4APDE4B | |
| SCHEMBL17066298 | 0.76 | PREP (0.50) | PREPMEN1KMT2AMAPTNPC1 | |
| SCHEMBL2709941 | 0.76 | PREP (0.42) | PREPMEN1KMT2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002281-B1 | ANTIVIRAL COMPOUNDS | GILEAD PHARMASSET LLC (US) | 2017-09-13 | — | — | EP | disclosed |